Paddy Power bookmaker make Arsenal long betting odds of 15/8 as these two Premiership heavyweights line up at the Emirates, hoping to catch Manchester City who have opened up a three point lead at the top of the table.
It will be the second time the two have met in the Premier League this season, after the memorable 8-2 win for United at Old Trafford earlier in the season.
The Gunners will be looking to put that memory well and truly behind them on Saturday, though, by securing the three points.
Since that fateful day in August, the Gunners have slowly but surely turned their season around, and are now in contention for Champions League qualification.
There are sure to be goals in this one, with Wayne Rooney looking to build on the hat-trick he scored when the sides last met, and Robin Van Persie looking to continue his imperious goal scoring form.
United know that this is a must win game, with their local rivals, Manchester City currently three points ahead of them in the title race.
They have attracted much criticism this season for their performances, but with the return of Paul Scholes, they could be all set for one final title push.
The latest team news coming out of Old Trafford is thatDavid De Gea has struggled to settle in English football this season, and now it appears that Sir Alex Ferguson has given up hope of him coming good.
The young Spaniard has been dropped by Ferguson in Manchester United’s recent games, with Danish keeper, Anders Lindegaard getting the nod.
However, reports are now suggesting that United will look to sign Swansea’s Michel Vorm in the summer.Vorm has been in impressive form this season, and has been responsible for many of the Swans’ clean-sheets.
He has been on the radar of many top clubs for a number of years now, including United and Chelsea, but most have been put off by his lack of height.
But his six foot frame has not proved to be too much of a problem this season, as he has earned rave reviews for his performances in the Swansea goal.
However, United have more pressing concerns in the short-term, with Arsenal sure to provide a stiff test today.
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